DAILY MLB PREVIEW

MLB Game Day Preview — Tuesday, September 22, 2026

Today's starting pitchers, key matchups, lineup updates and games to watch.

First pitch1:05 PM ET
Last first pitch10:10 PM ET
Slate data updated8:30 AM ET
16
Games
29
Confirmed starters
9
Division matchups
0
Lineups confirmed
3
TBD starters
9h 5m
Slate window
Today in 30 seconds
DUELMessick and Tolle combine for a 147 P-Score, the highest total among today's confirmed starter pairs.
GAPLargest starter gap: Gilbert (61) against Javier (38).
RACELAA at ATH is today's closest division matchup.
WINDMain weather concern: 13 mph at Yankee Stadium.
Updated 8:30 AM ET.

Games to watch

Playoff Game To Watch9:40 PM ET

Angels and Athletics Meet With Playoff Position at Stake

NoteThe teams are separated by 1 game in the division race.
NoteAthletics holds the edge at 17 games back.
Open matchup
Best Pitching Duel6:45 PM ET

Messick vs Tolle in Boston Red

Combined P-Score147
Last-5 ERA2.10 · 3.21
Open matchup
Division Game To Watch6:35 PM ET

Jays-Orioles Is a Division Game to Watch

Combined P-Score76
NoteJays and Orioles are division opponents tonight.
NoteThey enter separated by 2 games in the standings.
Open matchup

Pitching spotlight

1 / 3

Full slate

StatusMatchupT-ScoreProbable pitchersP-ScoreLineupsScore
1:05 PM
6871
Martinez 2.94Rodón 2.95
6059
Pending
6:35 PM
4749
Scherzer 6.07Bassitt 4.64
3145
Pending
6:40 PM
4152
Pallante 3.70Jones 4.17
5758
Pending
6:40 PM
7655
May 4.61Wheeler 2.99
5370
Pending
6:40 PM
5253
Kent 6.40Anderson 3.62
3252
Pending
6:45 PM
5557
Messick 2.57Tolle 3.02
7671
Pending
7:05 PM
6871
Rasmussen 2.72Fried 2.63
7471
Pending
7:15 PM
2959
2740
Pending
7:40 PM
5635
Kay 4.41Lynch 3.29
4744
Pending
7:40 PM
5167
Junk 4.50TBD
46
Pending
8:05 PM
4447
Manaea 4.74TBD
50
Pending
8:40 PM
4825
Soroka 3.45Freeland 6.38
6143
Pending
9:40 PM
4844
Javier 5.31Gilbert 3.69
3861
Pending
9:40 PM
3625
Kikuchi 5.02Basso 4.50
44
Pending
9:45 PM
4541
Bradley 3.81Molina 4.18
59
Pending
10:10 PM
5573
King 3.03TBD
60
Pending
Lineup tracker
ConfirmedOfficial cards filed with the league
0
ProjectedBuilt from last seven games
0
PendingNo order and no projection yet
16