Pittsburgh Pirates vs New York Yankees Starting Lineup — Wednesday, Jul 22, 2026

Brandon Lowe has by far the deepest history against Gerrit Cole, going 7-for-33 in 36 PA with a .212 average and .581 OPS. Bryan Reynolds has a small but positive sample at 1-for-2 in 3 PA with a .500 average and 1.167 OPS, while Ryan O'Hearn is 2-for-19 with a .105 average and .421 OPS. Jacob Gonzalez is hitless against Cole, with a 0-for-2 line in 2 PA and a .000 OPS, and Jake Mangum, Esmerlyn Valdez, Nick Gonzales, Henry Davis, and Tyler Callihan have no MLB history vs him.

Trent Grisham has handled Mitch Keller well, going 3-for-6 with a .500 average and 1.000 OPS, and Cody Bellinger is 5-for-13 with a .385 average and 1.077 OPS. Ben Rice is 1-for-2 in 3 PA with a .500 average and 1.167 OPS, while Jasson Domínguez is 2-for-2 with a 1.000 average and 2.500 OPS in a very limited sample. Ryan McMahon is 1-for-8 in 10 PA with a .125 average and .550 OPS, Austin Wells is hitless at 0-for-2 in 3 PA with a .333 OPS, Jazz Chisholm Jr. has 1 PA with one walk, and Spencer Jones and José Caballero have no MLB history vs Keller.

The Yankees side clearly brings more familiarity into this matchup, with several hitters owning productive prior results against Keller. The opposing group has one substantial sample in Lowe, but otherwise much less experience against Cole.