San Francisco has no established MLB history against Luinder Avila. Heliot Ramos, Bryce Eldridge, Casey Schmitt, Rafael Devers, Willy Adames, Jung Hoo Lee, Jesus Rodriguez, Drew Gilbert, and Christian Koss all have no MLB history vs this pitcher. That leaves the Giants lineup almost entirely without prior exposure entering this matchup.
Kansas City has a few hitters with experience against Tyler Mahle, led clearly by Starling Marte, who is 7-for-15 with a .467 average and 1.134 OPS. Lane Thomas has the largest sample in the lineup but has gone 1-for-12 with a .083 average and .166 OPS, while Salvador Perez is hitless in 3 at-bats, going 0-for-3 with a .000 OPS. Vinnie Pasquantino is hitless in 1 at-bat at 0-for-1 with a .000 OPS, and Michael Massey is hitless in 3 at-bats at 0-for-3 with a .000 OPS. Carter Jensen, Jac Caglianone, Nick Loftin, and Tyler Tolbert have no MLB history vs this pitcher.
The Royals have far more familiarity with the opposing starter, even if most of that history is mixed outside of Marte’s strong track record. The Giants, by contrast, are facing Avila with a completely clean slate.